Endocrine Abstracts

Testosterone is a coronary vasodilator and is known to increase ischaemic threshold in men with angina. We have previously demonstrated that testosterone inhibits the pore forming alpha1c subunit of the cardiovascular L-type calcium channel transfected into HEK293 cells. In this study we have investigated the effect of testosterone on potassium-stimulated extracellular calcium entry in A7r5 vascular smooth muscle cells (VSMCs).A7r5 cells grown...

Testosterone therapy has been shown to be beneficial in men with coronary artery disease (CAD) and chronic heart failure (CHF), effects which are proposed to be due to a direct vasodilatory action. We utilised fluorescence measurements to investigate whether testosterone inhibits extracellular calcium entry induced by 50mM high potassium (K+) buffer, in A7r5 vascular smooth muscle cells.A7r5 cells were grown on coverslips in 12-well plates in ...